Geriatric
Medicine
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Geriatric Medicine
School of Clinical Sciences & Community Health
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Professor Alasdair MacLullich
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Position |
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Professor of Geriatric Medicine |
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Head of Section |
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Qualifications
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BSc (Hons), MB ChB, MRCP (UK), PhD |
Email
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a.maclullich@ed.ac.uk |
Phone
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0131 242 4682/6481 |
Fax
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0131 242 6370 |
Address
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Room F1424, Royal Infirmary
of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA
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Biography
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Following
undergraduate medical training (including an intercalated BSc in Psychology)
at the University of Edinburgh, Professor MacLullich completed a medical training
rotation at the Western General Hospital and went on to do a PhD on
glucocorticoids and cognitive ageing. He was Clinical Lecturer in Geriatric Medicine from
2000-2005 and was awarded an MRC Clinician Scientist Fellowship in 2005 to
work on the pathophysiology of delirium. |
Professional Membership
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British Geriatrics Society |
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European Delirium Association |
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Broad Areas of interest:
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Research
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Pathophysiology of delirium,
particularly the role of glucocorticoids and inflammation |
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Neuroimaging in delirium |
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Neuropsychology of delirium |
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Role of glucocorticoids in
chronic cognitive ageing |
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Neuroimaging correlates of
cognition |
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Role of glucocorticoids and
inflammation in skeletal muscle loss |
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Clinical
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Acute
geriatric medicine |
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Teaching
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Module leader, Year 5 Geriatric
Medicine |
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Contributor to local and
national NHS teaching events |
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Lecturer on Neuroscience,
Endocrine Pharmacology and Medical Biology Honours courses |
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Contributor to University of
Edinburgh Certificate in Translational Medicine |
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Methodological skills
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Cognitive testing of older
adults |
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Assessment of delirium |
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Assessment of dementia |
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Structural neuroimaging |
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Glucocorticoid assays (blood,
saliva, urine, CSF) |
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Other information
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Professor MacLullich
co-founded and is the Secretary of the European Delirium Association.
www.europeandeliriumassociation.com |
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Publications (2003 onwards):
Ferguson KJ, Wardlaw JM, MacLullich AMJ. Quantitative and qualitative measures
of hippocampal atrophy are not correlated in healthy older men. Journal of
Neuroimaging (in press)
Brown LJ, McGrory S, McClaren L, Starr JM, Deary IJ,
Maclullich AM. Cognitive visual perceptual deficits in delirium. J Neurol
Neurosurg Psychiatry. 2009 Feb 22. [Epub ahead of print]
MacLullich AM, Beaglehole A, Hall RJ, Meagher DJ. Delirium
and long-term cognitive impairment. Int Rev Psychiatry. 2009
Feb;21(1):30-42.
Soiza RL, Sharma V, Ferguson K, Shenkin SD, Seymour DG,
Maclullich AM. Neuroimaging studies of delirium: a systematic review. J
Psychosom Res. 2008 Sep;65(3):239-48.
Maclullich AM, Ferguson KJ, Miller T, de Rooij SE,
Cunningham C. Unravelling the pathophysiology of delirium: a focus on the role
of aberrant stress responses. J Psychosom Res. 2008 Sep;65(3):229-38.
Meagher DJ, Maclullich AM, Laurila JV. Defining delirium
for the International Classification of Diseases, 11th Revision. J Psychosom
Res. 2008 Sep;65(3):207-14.
Farrell C, Chappell F, Armitage PA, Keston P, Maclullich A,
Shenkin S, Wardlaw JM. Development and initial testing of normal reference MR
images for the brain at ages 65-70 and 75-80 years. Eur Radiol. 2009
Jan;19(1):177-83.
Bastin ME, Piatkowski JP, Storkey AJ, Brown LJ, Maclullich
AM, Clayden JD. Tract shape modelling provides evidence of topological change in
corpus callosum genu during normal ageing. Neuroimage. 2008 Oct
15;43(1):20-8.
MacLullich AM, Seckl JR. Diabetes and cognitive decline:
are steroids the missing link? Cell Metab. 2008 Apr;7(4):286-7.
MacLullich AM, Starr JM, Passmore AP. Delirium should be
included in guidelines and curriculums. BMJ. 2007 May 12;334(7601):968.
MacLullich AM, Meagher DJ, Laurila JV, Kalisvaart KJ.The
European delirium association. J Psychosom Res. 2007 Mar;62(3):397-8.
MacLullich AM, Ferguson KJ, Wardlaw JM, Starr JM, Deary IJ,
Seckl JR. (2006). Smaller left anterior cingulate cortex volumes are associated
with impaired hypothalamic-pituitary-adrenal axis regulation in healthy elderly
men. Journal of Clin Endocrinol Metab Feb. 7 (Epub ahead of print)
Ferguson KJ, Wardlaw JM, Edmond CL, Deary IJ, MacLullich AMJ. (2005).
Intracranial area: a validated method for estimating intracranial volume.
Journal of Neuroimaging 15, 76-78
MacLullich AMJ, Deary IJ, Starr JM,
Ferguson KJ, Wardlaw JM, Seckl JR. (2005). Plasma
cortisol levels, brain volume and cognition in healthy elderly men.
Psychoneuroendocrinology 30: 505-515
MacLullich AMJ, Deary IJ, Starr JM, Walker BR, Seckl
JR. Glycosylated hemoglobin levels in healthy elderly non-diabetic men are
negatively associated with verbal memory. (2004). Journal of the American
Geriatrics Society 52: 848-849
MacLullich AMJ, Edmond CL, Ferguson KJ, Wardlaw JM, Starr JM, Seckl JR,
Deary IJ. (2004). Size of the neocerebellar vermis is associated with
cognition in healthy elderly men. Brain and Cognition 56: 344-348
Marshall I, Simonotto E, Deary IJ, MacLullich AMJ,
Ebmeier KP, Rose E, Wardlaw JM, Goddard N, Chappell FM. (2004).
Repeatability of motor and working memory tasks in healthy older volunteers.
Radiology 233: 868-877
MacLullich AMJ, Wardlaw JM, Ferguson KJ, Starr JM, Seckl JR, & Deary IJ.
(2004). Enlarged perivascular spaces are associated with cognitive function
in healthy elderly men. Journal of Neurology Neurosurgery and Psychiatry 75:
1519-1532
Sandeep TC, Yau JLW, MacLullich AMJ, Noble J, Deary
IJ, Walker BR & Seckl JR. (2004). 11ß-hydroxysteroid dehydrogenase type 1,
but not 2, is expressed in the human hippocampus, cerebellum and frontal cortex:
effects of its inhibition on cognitive function in healthy elderly men and
patients with type 2 diabetes. P Natl Acad Sci USA 101: 6734-6739
MacLullich AMJ,
Deary IJ, Marshall I. (2003). Increased blood-brain barrier permeability in type
II diabetes demonstrated by gadolinium magnetic resonance imaging. Journal of
neurology neurosurgery and psychiatry 74: 70-76
Starr JM, Wardlaw JM, Ferguson KJ, MacLullich AMJ, Deary IJ, Marshall I.
(2003). Increased blood-brain barrier permeability in type II diabetes
demonstrated by gadolinium magnetic resonance imaging. Journal of Neurology
Neurosurgery and Psychiatry 74: 70-76
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